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Brain endothelial GSDMD activation mediates inflammatory BBB breakdown.
Nature. 2024 Apr 17. doi: 10.1038/s41586-024-07314-2. Online ahead of print.
Nature. 2024.
PMID: 38632402
Pyroptosis inhibiting nanobodies block Gasdermin D pore formation.
Kopp A, Hagelueken G, Jamitzky I, Moecking J, Schiffelers LDJ, Schmidt FI, Geyer M.
Kopp A, et al. Among authors: schiffelers ldj.
Nat Commun. 2023 Dec 1;14(1):7923. doi: 10.1038/s41467-023-43707-z.
Nat Commun. 2023.
PMID: 38040708
Free PMC article.
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P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection.
Jenster LM, Lange KE, Normann S, vom Hemdt A, Wuerth JD, Schiffelers LDJ, Tesfamariam YM, Gohr FN, Klein L, Kaltheuner IH, Ebner S, Lapp DJ, Mayer J, Moecking J, Ploegh HL, Latz E, Meissner F, Geyer M, Kümmerer BM, Schmidt FI.
Jenster LM, et al. Among authors: schiffelers ldj.
J Exp Med. 2023 Jan 2;220(1):e20220837. doi: 10.1084/jem.20220837. Epub 2022 Oct 31.
J Exp Med. 2023.
PMID: 36315050
Free PMC article.
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Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape.
Koenig PA, Das H, Liu H, Kümmerer BM, Gohr FN, Jenster LM, Schiffelers LDJ, Tesfamariam YM, Uchima M, Wuerth JD, Gatterdam K, Ruetalo N, Christensen MH, Fandrey CI, Normann S, Tödtmann JMP, Pritzl S, Hanke L, Boos J, Yuan M, Zhu X, Schmid-Burgk JL, Kato H, Schindler M, Wilson IA, Geyer M, Ludwig KU, Hällberg BM, Wu NC, Schmidt FI.
Koenig PA, et al. Among authors: schiffelers ldj.
Science. 2021 Feb 12;371(6530):eabe6230. doi: 10.1126/science.abe6230. Epub 2021 Jan 12.
Science. 2021.
PMID: 33436526
Free PMC article.
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