High efficacy of CD19 CAR T-cells in patients with transformed Waldenström macroglobulinemia

Eric Durot; Damien Roosweil; Adrien Chauchet; Justine Decroocq; Roberta Di Blasi; Thomas Gastinne; Hedi Bensaber; Morgane Cheminant; Caroline Jacquet; Stéphanie Guidez; Francois-Xavier Gros; Emmanuel Bachy; Arthur Coste; Pascale Cony-Makhoul; Steven P Treon; Alain Jacques Delmer; Ran Reshef; Steven Le Gouill; Jorge J Castillo; Roch Houot

doi:10.1182/blood.2024024452

High efficacy of CD19 CAR T-cells in patients with transformed Waldenström macroglobulinemia

Blood. 2024 Apr 26:blood.2024024452. doi: 10.1182/blood.2024024452. Online ahead of print.

Authors

Eric Durot¹, Damien Roosweil², Adrien Chauchet³, Justine Decroocq⁴, Roberta Di Blasi⁵, Thomas Gastinne⁶, Hedi Bensaber⁷, Morgane Cheminant⁸, Caroline Jacquet⁹, Stéphanie Guidez¹⁰, Francois-Xavier Gros¹¹, Emmanuel Bachy¹², Arthur Coste¹³, Pascale Cony-Makhoul¹⁴, Steven P Treon¹⁵, Alain Jacques Delmer¹⁶, Ran Reshef¹⁷, Steven Le Gouill¹⁸, Jorge J Castillo¹⁹, Roch Houot²⁰

Affiliations

¹ Hôpital Robert Debré CHU de Reims, Reims cedex, France.
² Sorbonne Université, Groupe Hospitalier Pitié-Salpêtrière, Paris, France.
³ CHU, Besancon, France.
⁴ Université de Paris, Institut Cochin, CNRS UMR8104, INSERM U1016, F-75014 Paris, France, Paris, France.
⁵ Hopital Saint Louis, PARIS, France.
⁶ Centre hospitalo-Universitaire, Nantes, France.
⁷ University Hospital of Clermont-Ferrand, Clermont-Ferrand, France.
⁸ Hôpital Necker, APHP, paris, France.
⁹ CHRU de Nancy, Vandœuvre-lès-Nancy, France.
¹⁰ CHU de Poitiers.
¹¹ CHU Bordeaux, Bordeaux, France.
¹² Hospices Civils de Lyon, Pierre-Bénite, France.
¹³ Hopital Robert Debre CHU de Reims, Reims cedex, France.
¹⁴ LYSARC, Pierre-Benite cedex, France.
¹⁵ Dana Farber Cancer Institute, Boston, Massachusetts, United States.
¹⁶ Hopital Robert Debre, REIMS, France.
¹⁷ Columbia University Medical Center, New York, New York, United States.
¹⁸ Institut Curie, Paris, France.
¹⁹ Dana-Farber Cancer Institute, Boston, Massachusetts, United States.
²⁰ CHU Rennes, Rennes, France.

PMID: 38669635
DOI: 10.1182/blood.2024024452

Abstract

Histological transformation of Waldenström macroglobulinemia (HT-WM) carries a poor prognosis with standard treatments. Here, we report the first series of HT-WM treated with CAR T-cells showing a high efficacy and no unexpected toxicity.