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Nanoparticles can cause DNA damage across a cellular barrier.
Bhabra G, Sood A, Fisher B, Cartwright L, Saunders M, Evans WH, Surprenant A, Lopez-Castejon G, Mann S, Davis SA, Hails LA, Ingham E, Verkade P, Lane J, Heesom K, Newson R, Case CP. Bhabra G, et al. Among authors: evans wh. Nat Nanotechnol. 2009 Dec;4(12):876-83. doi: 10.1038/nnano.2009.313. Nat Nanotechnol. 2009. PMID: 19893513
Signalling of DNA damage and cytokines across cell barriers exposed to nanoparticles depends on barrier thickness.
Sood A, Salih S, Roh D, Lacharme-Lora L, Parry M, Hardiman B, Keehan R, Grummer R, Winterhager E, Gokhale PJ, Andrews PW, Abbott C, Forbes K, Westwood M, Aplin JD, Ingham E, Papageorgiou I, Berry M, Liu J, Dick AD, Garland RJ, Williams N, Singh R, Simon AK, Lewis M, Ham J, Roger L, Baird DM, Crompton LA, Caldwell MA, Swalwell H, Birch-Machin M, Lopez-Castejon G, Randall A, Lin H, Suleiman MS, Evans WH, Newson R, Case CP. Sood A, et al. Among authors: evans wh. Nat Nanotechnol. 2011 Nov 6;6(12):824-33. doi: 10.1038/nnano.2011.188. Nat Nanotechnol. 2011. PMID: 22056725
Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury.
Wang N, De Vuyst E, Ponsaerts R, Boengler K, Palacios-Prado N, Wauman J, Lai CP, De Bock M, Decrock E, Bol M, Vinken M, Rogiers V, Tavernier J, Evans WH, Naus CC, Bukauskas FF, Sipido KR, Heusch G, Schulz R, Bultynck G, Leybaert L. Wang N, et al. Among authors: evans wh. Basic Res Cardiol. 2013 Jan;108(1):309. doi: 10.1007/s00395-012-0309-x. Epub 2012 Nov 8. Basic Res Cardiol. 2013. PMID: 23184389 Free PMC article.
Connexin channels provide a target to manipulate brain endothelial calcium dynamics and blood-brain barrier permeability.
De Bock M, Culot M, Wang N, Bol M, Decrock E, De Vuyst E, da Costa A, Dauwe I, Vinken M, Simon AM, Rogiers V, De Ley G, Evans WH, Bultynck G, Dupont G, Cecchelli R, Leybaert L. De Bock M, et al. Among authors: evans wh. J Cereb Blood Flow Metab. 2011 Sep;31(9):1942-57. doi: 10.1038/jcbfm.2011.86. Epub 2011 Jun 8. J Cereb Blood Flow Metab. 2011. PMID: 21654699 Free PMC article.
279 results