LGI1-antibody encephalitis: how to approach this highly treatable dementia mimic in memory and mental health services

Sophie N M Binks; Adam Al-Diwani; Adam E Handel; Tomasz Bajorek; Sanjay Manohar; Masud Husain; Sarosh R Irani; Ivan Koychev

doi:10.1192/bjp.2024.72

LGI1-antibody encephalitis: how to approach this highly treatable dementia mimic in memory and mental health services

Br J Psychiatry. 2024 May 3:1-6. doi: 10.1192/bjp.2024.72. Online ahead of print.

Authors

Sophie N M Binks^{1

2}, Adam Al-Diwani^{3

4

5}, Adam E Handel^{1

2

4

5}, Tomasz Bajorek⁴, Sanjay Manohar^{2

6

7}, Masud Husain^{2

6

7}, Sarosh R Irani^{1

2}, Ivan Koychev⁸

Affiliations

¹ Oxford Autoimmune Neurology Group, Nuffield Department of Clinical Neurosciences, University of Oxford, UK.
² Department of Neurology, John Radcliffe Hospital, Oxford University Hospital NHS Foundation Trust, Oxford, UK.
³ University Department of Psychiatry, University of Oxford, UK.
⁴ Department of Psychological Medicine, John Radcliffe Hospital, Oxford University Hospital NHS Foundation Trust, Oxford, UK.
⁵ Oxford Community Psychological Medicine Service, Oxford Health NHS Foundation Trust, Oxford, UK.
⁶ Department of Experimental Psychology, University of Oxford, UK.
⁷ Nuffield Department of Clinical Neurosciences, University of Oxford, UK.
⁸ University Department of Psychiatry, University of Oxford, UK; and Department of Psychological Medicine, John Radcliffe Hospital, Oxford University Hospital NHS Foundation Trust, Oxford, UK.

PMID: 38699852
DOI: 10.1192/bjp.2024.72

Abstract

Leucine-rich glioma-inactivated 1-antibody-encephalitis is a treatable and potentially reversible cause of cognitive and psychiatric presentations, and may mimic cognitive decline, rapidly progressive dementia and complex psychosis in older patients. This aetiology is of immediate relevance given the alternative treatment pathway required, compared with other conditions presenting with cognitive deficits.

Keywords: Dementia; leucine-rich glioma-inactivated 1; neuroimmunology; older adults; psychosis.

Publication types

Review

Abstract

Publication types

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