No pathogenic mutations in the persyn gene in Parkinson's disease

S Lincoln; K Gwinn-Hardy; J Goudreau; M C Chartier-Harlin; M Baker; V Mouroux; F Richard; A Destée; E Becquet; P Amouyel; T Lynch; J Hardy; M Farrer

doi:10.1016/s0304-3940(98)00901-x

No pathogenic mutations in the persyn gene in Parkinson's disease

Neurosci Lett. 1999 Jan 4;259(1):65-6. doi: 10.1016/s0304-3940(98)00901-x.

Authors

S Lincoln¹, K Gwinn-Hardy, J Goudreau, M C Chartier-Harlin, M Baker, V Mouroux, F Richard, A Destée, E Becquet, P Amouyel, T Lynch, J Hardy, M Farrer

Affiliation

¹ Mayo Clinic Jacksonville, FL 32084, USA.

PMID: 10027558
DOI: 10.1016/s0304-3940(98)00901-x

Abstract

The persyn (gamma-synuclein) gene is highly homologous to the alpha-synuclein gene and is highly expressed in the nervous system. It is therefore, an excellent candidate gene for Parkinson's disease. However, we have sequenced the gene in a large number of families with parkinsonism and failed to find pathogenic mutations.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Age of Onset
Aged
Humans
Middle Aged
Mutation / genetics*
Neoplasm Proteins*
Nerve Tissue Proteins / genetics*
Parkinson Disease / etiology
Parkinson Disease / genetics*
Sequence Analysis, DNA / methods
gamma-Synuclein

Substances

Neoplasm Proteins
Nerve Tissue Proteins
SNCG protein, human
gamma-Synuclein