Envisioning the molecular choreography of DNA base excision repair

Curr Opin Struct Biol. 1999 Feb;9(1):37-47. doi: 10.1016/s0959-440x(99)80006-2.

Abstract

Recent breakthroughs integrate individual DNA repair enzyme structures, biochemistry and biology to outline the structural cell biology of the DNA base excision repair pathways that are essential to genome integrity. Thus, we are starting to envision how the actions, movements, steps, partners and timing of DNA repair enzymes, which together define their molecular choreography, are elegantly controlled by both the nature of the DNA damage and the structural chemistry of the participating enzymes and the DNA double helix.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Base Pair Mismatch
  • Carbon-Oxygen Lyases / chemistry
  • Carbon-Oxygen Lyases / metabolism
  • DNA Glycosylases*
  • DNA Ligases / chemistry*
  • DNA Ligases / metabolism*
  • DNA Polymerase beta / chemistry
  • DNA Polymerase beta / metabolism
  • DNA Repair / physiology*
  • DNA-(Apurinic or Apyrimidinic Site) Lyase
  • Deoxyribonuclease IV (Phage T4-Induced)
  • Endodeoxyribonucleases / chemistry
  • Endodeoxyribonucleases / metabolism
  • Flap Endonucleases
  • Humans
  • Models, Molecular
  • N-Glycosyl Hydrolases / chemistry
  • N-Glycosyl Hydrolases / metabolism
  • Protein Conformation
  • Thymine DNA Glycosylase*
  • Uracil-DNA Glycosidase

Substances

  • DNA Polymerase beta
  • Endodeoxyribonucleases
  • Flap Endonucleases
  • FEN1 protein, human
  • Deoxyribonuclease IV (Phage T4-Induced)
  • DNA Glycosylases
  • N-Glycosyl Hydrolases
  • Thymine DNA Glycosylase
  • Uracil-DNA Glycosidase
  • mismatch-specific thymine uracil-DNA glycosylase
  • mutY adenine glycosylase
  • Carbon-Oxygen Lyases
  • DNA-(Apurinic or Apyrimidinic Site) Lyase
  • DNA Ligases