PIP: Hexachlorophene (HCP) in dosages of 0, 5, or 10 mg/kg/day was administered by gavage to 30 male and 60 female rats for 63 and 14 days, respectively, prior to mating. Dosing was continued until Day 14 of gestation for 1/2 the females and until after weaning for the other 1/2. Mating and fertility were not affected, and progeny were delivered in normal numbers, were free of structural abnormalities, and developed normally throughout lactation. A slight reduction in pup survival was observed at the 10 mg/kg dose level. Treatment of females with either 15 or 30 mg HCP/kg/day during the last third of gestation and until weaning caused reductions in the body weights and survival of the progeny. Reduced body-weight gain and some deaths were found among the maternal animals treated with 30 mg HCP/kg/day. At this level, an increase in stillbirths was seen, although all progeny, viable and stillborn, were structurally normal.