Abstract
After 2 weeks of nicorandil therapy, time to ischemia on stress testing was significantly less than on day 1 and not different from placebo. These data are consistent with attenuation of the anti-ischemic effects of this drug and suggest that the potassium channel-opening properties do not compensate for development of attenuation to the nitrate component of nicorandil.
Publication types
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Clinical Trial
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Adrenergic beta-Antagonists / therapeutic use
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Adult
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Aged
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Angina Pectoris / drug therapy*
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Angina Pectoris / physiopathology
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Blood Pressure / drug effects
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Calcium Channel Blockers / therapeutic use
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Cross-Over Studies
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Diltiazem / therapeutic use
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Double-Blind Method
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Electrocardiography
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Exercise Test
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Female
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Heart Rate / drug effects
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Humans
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Male
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Middle Aged
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Myocardial Ischemia / prevention & control
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Nicorandil / administration & dosage
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Nicorandil / therapeutic use*
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Time Factors
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Verapamil / therapeutic use
Substances
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Adrenergic beta-Antagonists
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Calcium Channel Blockers
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Nicorandil
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Verapamil
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Diltiazem