Central pain after pontine infarction is associated with changes in opioid receptor binding: a PET study with 11C-diprenorphine

AJNR Am J Neuroradiol. 1999 Apr;20(4):686-90.

Abstract

Using 18F-fluorodeoxyglucose and 11C-diprenorphine positron emission tomography (PET), we investigated alterations in glucose metabolism and opioid receptor binding in a patient with central poststroke pain, which developed after a small pontine hemorrhagic infarction. In comparison with normal databases, reduced 11C-diprenorphine binding was more accentuated than the hypometabolism on the lateral cortical surface contralateral to the symptoms, and a differential abnormal distribution between the tracers was seen in pain-related central structures. These results show that 11C-diprenorphine PET provides unique information for the understanding of central poststroke pain.

Publication types

  • Case Reports
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Carbon Radioisotopes*
  • Cerebral Hemorrhage / complications
  • Cerebral Infarction / complications*
  • Cerebral Infarction / metabolism
  • Cerebrovascular Disorders / complications
  • Cerebrovascular Disorders / metabolism
  • Diprenorphine* / pharmacology
  • Fluorodeoxyglucose F18
  • Glucose / metabolism
  • Humans
  • Male
  • Middle Aged
  • Narcotic Antagonists* / pharmacology
  • Pain / etiology*
  • Pain / metabolism
  • Pons / blood supply*
  • Pons / diagnostic imaging
  • Radiopharmaceuticals*
  • Receptors, Opioid / metabolism*
  • Sensation Disorders / etiology*
  • Sensation Disorders / metabolism
  • Tomography, Emission-Computed*

Substances

  • Carbon Radioisotopes
  • Narcotic Antagonists
  • Radiopharmaceuticals
  • Receptors, Opioid
  • Fluorodeoxyglucose F18
  • Diprenorphine
  • Glucose