Abstract
Although pellagra is a recognized complication of isoniazid therapy, the diagnosis may be overlooked or delayed--sometimes with life-threatening consequences. We report a case of isoniazid-induced pellagra which occurred despite pyridoxine supplementation. Drug withdrawal and supplementation with niacin led to a rapid and sustained clinical improvement. The possible mechanisms of isoniazid induced pellagra are discussed.
MeSH terms
-
Anti-Inflammatory Agents / therapeutic use
-
Antitubercular Agents / administration & dosage
-
Antitubercular Agents / adverse effects*
-
Clobetasol / therapeutic use
-
Drug Therapy, Combination
-
Humans
-
Isoniazid / administration & dosage
-
Isoniazid / adverse effects*
-
Male
-
Middle Aged
-
Niacinamide / therapeutic use
-
Pellagra / chemically induced*
-
Pellagra / diagnosis
-
Pellagra / drug therapy
-
Pyridoxine / administration & dosage*
-
Sunscreening Agents / therapeutic use
Substances
-
Anti-Inflammatory Agents
-
Antitubercular Agents
-
Sunscreening Agents
-
Niacinamide
-
Clobetasol
-
Pyridoxine
-
Isoniazid