Flurbiprofen, S(+), eyedrops: formulation, enantiomeric assay, shelf-life and pharmacology

Pharm World Sci. 1999 Apr;21(2):91-5. doi: 10.1023/a:1008609513880.

Abstract

Aphakic cystoid macula edema, occurring after cataract extraction is ascribed to trauma-induced production of intra-ocular prostaglandins. Sufficient experimental and clinical evidence supports the use of prostaglandin synthesis inhibitors to countervail this clinical condition. The active S(+)-enantiomer of flurbiprofen, a prostaglandin synthesis inhibitor, has been formulated into a stereoselective, ballast free eyedrop solution in a concentration of 0.015%. Analysis by capillary zone electrophoresis shows shelf-life stability up to four years at room temperature of this enantiomer. The inhibitory effect on the synthesis of prostaglandins as measured on a homogenate bovine iris/ciliary body, remained unaffected during a shelf-life period of three years.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Cattle
  • Dose-Response Relationship, Drug
  • Drug Stability
  • Electrophoresis, Capillary
  • Flurbiprofen / chemistry*
  • Flurbiprofen / pharmacology*
  • In Vitro Techniques
  • Ophthalmic Solutions / chemistry*
  • Ophthalmic Solutions / pharmacology
  • Prostaglandins / biosynthesis*
  • Stereoisomerism

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Ophthalmic Solutions
  • Prostaglandins
  • Flurbiprofen