(R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropionamides are orally active inhibitors of pyruvate dehydrogenase kinase

J Med Chem. 1999 Jul 29;42(15):2741-6. doi: 10.1021/jm9902584.
No abstract available

MeSH terms

  • Administration, Oral
  • Amides / chemical synthesis*
  • Amides / chemistry
  • Amides / pharmacokinetics
  • Amides / pharmacology
  • Animals
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacokinetics
  • Enzyme Inhibitors / pharmacology
  • Fibroblasts
  • Humans
  • In Vitro Techniques
  • Lactic Acid / metabolism
  • Propionates / chemical synthesis*
  • Propionates / chemistry
  • Propionates / pharmacokinetics
  • Propionates / pharmacology
  • Protein Kinase Inhibitors*
  • Protein Kinases*
  • Protein Serine-Threonine Kinases
  • Pyruvate Dehydrogenase Acetyl-Transferring Kinase
  • Rats
  • Stereoisomerism
  • Structure-Activity Relationship

Substances

  • Amides
  • Enzyme Inhibitors
  • Propionates
  • Protein Kinase Inhibitors
  • Pyruvate Dehydrogenase Acetyl-Transferring Kinase
  • Lactic Acid
  • Protein Kinases
  • Protein Serine-Threonine Kinases