Synthesis and enantiomeric separation of 2-phthalimidino-glutaric acid analogues: potent inhibitors of tumor metastasis

J Med Chem. 1999 Aug 12;42(16):3014-7. doi: 10.1021/jm990083y.
No abstract available

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Drug Screening Assays, Antitumor
  • Glutarates / chemical synthesis*
  • Glutarates / chemistry
  • Glutarates / pharmacology
  • Indoles / chemical synthesis*
  • Indoles / chemistry
  • Indoles / pharmacology
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / secondary
  • Melanoma, Experimental / drug therapy
  • Melanoma, Experimental / secondary
  • Mice
  • Mice, Inbred C57BL
  • Neoplasm Transplantation
  • Stereoisomerism
  • Structure-Activity Relationship
  • Thalidomide / analogs & derivatives*
  • Thalidomide / chemical synthesis*
  • Thalidomide / chemistry
  • Thalidomide / pharmacology

Substances

  • 2-methyl-2-(1-oxoisoindol-2-yl)glutaric acid
  • Antineoplastic Agents
  • Glutarates
  • Indoles
  • Thalidomide