Gene silencing: Maintaining methylation patterns

Curr Biol. 1999 Aug 26;9(16):R617-9. doi: 10.1016/s0960-9822(99)80388-1.

Abstract

Recent studies of an Arabidopsis gene family have shown that inverted repeats can be potent silencers of other identical sequences in the genome, causing them to become stably methylated at cytosine residues. From mutations affecting this process we are beginning to understand how methylation patterns are maintained.

MeSH terms

  • Aldose-Ketose Isomerases / genetics
  • Alleles
  • Arabidopsis / enzymology
  • Arabidopsis / genetics*
  • Arabidopsis Proteins
  • Cytosine / metabolism
  • DNA Methylation
  • DNA-Binding Proteins / genetics
  • Gene Deletion
  • Gene Expression Regulation, Plant / genetics*
  • Gene Silencing*
  • Mutation
  • Transcription Factors / genetics

Substances

  • Arabidopsis Proteins
  • DDM1 protein, Arabidopsis
  • DNA-Binding Proteins
  • Transcription Factors
  • Cytosine
  • Aldose-Ketose Isomerases
  • phosphoribosylanthranilate isomerase