Genetic control of cortical regionalization and connectivity

Cereb Cortex. 1999 Sep;9(6):524-32. doi: 10.1093/cercor/9.6.524.

Abstract

Herein, the genetic control of regionalization and connectivity of the neocortex are reviewed. Evidence is accumulating which suggests that intrinsic mechanisms have a central role in controlling cortical regional specification and differentiation. Expression patterns of several genes (Id-2, Tbr-1, cadherin-6, cadherin-8, neuropilin-2, Wnt-7b, Eph-A7 and RZR-beta) are described; the expressions of these genes have regional boundaries which demarcate distinct functional areas of the cerebral cortex in neonatal mice.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Animals, Newborn
  • Axons / chemistry
  • Axons / physiology
  • Biomarkers
  • Brain Stem / cytology
  • Cadherins / genetics
  • DNA-Binding Proteins / genetics
  • Gene Expression Regulation, Developmental*
  • Glycoproteins*
  • Inhibitor of Differentiation Protein 2
  • Mice
  • Mice, Inbred Strains
  • Neocortex / cytology*
  • Neocortex / embryology*
  • Neocortex / growth & development
  • Nerve Tissue Proteins / genetics
  • Neural Pathways / cytology*
  • Neural Pathways / embryology*
  • Neural Pathways / growth & development
  • Neuropilin-1
  • Proto-Oncogene Proteins / genetics
  • RNA, Messenger / analysis
  • Receptor Protein-Tyrosine Kinases / genetics
  • Receptor, EphA7
  • Receptors, Cell Surface / genetics
  • Receptors, Cytoplasmic and Nuclear / genetics
  • Receptors, Melatonin
  • Repressor Proteins*
  • Spinal Cord / cytology
  • T-Box Domain Proteins
  • Thalamus / cytology
  • Transcription Factors*
  • Wnt Proteins

Substances

  • Biomarkers
  • Cadherins
  • Cdh8 protein, mouse
  • DNA-Binding Proteins
  • Glycoproteins
  • Idb2 protein, mouse
  • Inhibitor of Differentiation Protein 2
  • Nerve Tissue Proteins
  • Proto-Oncogene Proteins
  • RNA, Messenger
  • Receptors, Cell Surface
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Melatonin
  • Repressor Proteins
  • T-Box Domain Proteins
  • Tbr1 protein, mouse
  • Transcription Factors
  • Wnt Proteins
  • Wnt7b protein, mouse
  • Neuropilin-1
  • Receptor Protein-Tyrosine Kinases
  • Receptor, EphA7
  • K cadherin