Necrobiotic cutaneous T-cell lymphoma

J Am Acad Dermatol. 1999 Nov;41(5 Pt 2):815-9. doi: 10.1016/s0190-9622(99)70332-4.

Abstract

We report 3 patients with granulomatous cutaneous T-cell lymphoma (CTCL) who showed necrobiosis histologically with palisading granulomas. Although granulomatous change may be present in up to 4% of cases of CTCL, necrobiosis is rare. Misdiagnosis may occur if epidermotropism is minimal or if atypical cells are masked by the granulomatous infiltrate. T-cell receptor gene analysis confirmed the presence of clonal T-cell populations in lesional skin from all 3 cases.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Diagnosis, Differential
  • Female
  • Humans
  • Lymphoma, T-Cell, Cutaneous / diagnosis
  • Lymphoma, T-Cell, Cutaneous / pathology*
  • Male
  • Middle Aged
  • Mycosis Fungoides / diagnosis
  • Necrobiotic Disorders / pathology
  • Skin Neoplasms / diagnosis
  • Skin Neoplasms / pathology*