Twenty individuals underwent quantitative sensation testing (QST) before and after 1 dose of aspirin, acetaminophen, or acetaminophen with codeine to determine the effect of analgesics on QST results. There was no significant change from baseline when mean QST results after placebo were compared to mean QST results after analgesics. We conclude that the effect of small doses of simple analgesics on QST results is either not present or is too small to necessitate withholding analgesics before sensory testing.