Mapping of a gene responsible for dermatitis in NOA (Naruto Research Institute Otsuka Atrichia) mice, an animal model of allergic dermatitis

K Natori; M Tamari; O Watanabe; Y Onouchi; Y Shiomoto; S Kubo; Y Nakamura

doi:10.1007/s100380050181

Mapping of a gene responsible for dermatitis in NOA (Naruto Research Institute Otsuka Atrichia) mice, an animal model of allergic dermatitis

J Hum Genet. 1999;44(6):372-6. doi: 10.1007/s100380050181.

Authors

K Natori¹, M Tamari, O Watanabe, Y Onouchi, Y Shiomoto, S Kubo, Y Nakamura

Affiliation

¹ Laboratory of Molecular Medicine, University of Tokyo, Japan.

PMID: 10570907
DOI: 10.1007/s100380050181

Abstract

The NOA (Naruto Research Institute Otsuka Atrichia) mouse is an animal model of allergic or atopic dermatitis, a condition characterized by ulcerative skin lesions with accumulation of mast cells and increased serum IgE. These features of the murine disease closely resemble human atopy and atopic disorders. We performed linkage analysis in NOA back-cross progeny, as a step toward identifying and isolating a gene responsible for the NOA phenotype. We crossed NOA mice with five other murine strains (C57BL/6J, IQI, C3H/HeJ, DBA/2J, and BALB/cByJ) and then bred back-cross animals. Using microsatellite markers, we scanned the entire genomes of 559 N2 offspring from the five parental strains. Linkage analysis revealed a significant association between ulcerative skin lesions and markers on murine chromosome 14. Statistical analysis indicated that the critical region was assigned to the vicinity of D14Mit236 and D14Mit160.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Chromosome Mapping
Dermatitis, Atopic / genetics*
Disease Models, Animal*
Female
Genetic Linkage*
Humans
Male
Mice
Mice, Inbred Strains