Abstract
The recently determined structure of the lipid-binding 'FYVE' domain provides several clues to the mode of interaction for this class of peripheral membrane proteins. However, the application of traditional modes of structural analysis to diffusible membrane-binding proteins exposes some limitations of these techniques.
MeSH terms
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Animals
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Crystallography, X-Ray
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Humans
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Macromolecular Substances
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Magnetic Resonance Spectroscopy
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Membrane Lipids / chemistry
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Membrane Lipids / metabolism*
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Membrane Proteins / chemistry*
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Membrane Proteins / metabolism
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Micelles
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Models, Molecular
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Phosphatidylinositols / chemistry
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Phosphatidylinositols / metabolism*
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Protein Binding
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Protein Conformation
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Protein Structure, Tertiary*
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Signal Transduction
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Structure-Activity Relationship
Substances
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Macromolecular Substances
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Membrane Lipids
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Membrane Proteins
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Micelles
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Phosphatidylinositols