Peripheral membrane proteins: FYVE sticky fingers

Curr Biol. 1999 Nov 18;9(22):R857-60. doi: 10.1016/s0960-9822(00)80046-9.

Abstract

The recently determined structure of the lipid-binding 'FYVE' domain provides several clues to the mode of interaction for this class of peripheral membrane proteins. However, the application of traditional modes of structural analysis to diffusible membrane-binding proteins exposes some limitations of these techniques.

Publication types

  • Review

MeSH terms

  • Animals
  • Crystallography, X-Ray
  • Humans
  • Macromolecular Substances
  • Magnetic Resonance Spectroscopy
  • Membrane Lipids / chemistry
  • Membrane Lipids / metabolism*
  • Membrane Proteins / chemistry*
  • Membrane Proteins / metabolism
  • Micelles
  • Models, Molecular
  • Phosphatidylinositols / chemistry
  • Phosphatidylinositols / metabolism*
  • Protein Binding
  • Protein Conformation
  • Protein Structure, Tertiary*
  • Signal Transduction
  • Structure-Activity Relationship

Substances

  • Macromolecular Substances
  • Membrane Lipids
  • Membrane Proteins
  • Micelles
  • Phosphatidylinositols