Acyclic structural variants of growth hormone secretagogue L-692,429

P Lin; J M Pisano; W R Schoen; K Cheng; W W Chan; B S Butler; R G Smith; M H Fisher; M J Wyvratt

doi:10.1016/s0960-894x(99)00568-5

Acyclic structural variants of growth hormone secretagogue L-692,429

Bioorg Med Chem Lett. 1999 Nov 15;9(22):3237-42. doi: 10.1016/s0960-894x(99)00568-5.

Authors

P Lin¹, J M Pisano, W R Schoen, K Cheng, W W Chan, B S Butler, R G Smith, M H Fisher, M J Wyvratt

Affiliation

¹ Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA.

PMID: 10576695
DOI: 10.1016/s0960-894x(99)00568-5

Abstract

Systematic investigation of acyclic analogs of L-692,429, the prototype benzolactam growth hormone secretagogue, has helped to further define the structural requirements for the release of growth hormone from rat pituitary cells for this class of secretagogues.

MeSH terms

Animals
Benzazepines / chemistry*
Benzazepines / pharmacology
Cells, Cultured
Growth Hormone / metabolism
Molecular Structure
Pituitary Gland / chemistry
Pituitary Gland / drug effects
Rats
Tetrazoles / chemistry*
Tetrazoles / pharmacology

Substances

Benzazepines
Tetrazoles
L 692429
Growth Hormone