Abstract
The methanol extract of the dried roots of Ferula sumbul afforded two furanocoumarin esters, fesumtuorin A, B, one bicoumarin, fesumtuorin C, five spirobicoumarins, fesumtuorin D, E, F, G and H, along with nineteen known coumarins. Their structures were established on the basis of spectroscopic studies. Some of the isolated compounds showed anti-HIV activity and very weak inhibition of cytokine release.
MeSH terms
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Anti-HIV Agents / chemistry
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Anti-HIV Agents / isolation & purification*
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Anti-HIV Agents / pharmacology
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Apiaceae / chemistry*
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Cell Line
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Chromatography, High Pressure Liquid
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Coumarins / chemistry
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Coumarins / isolation & purification*
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Coumarins / pharmacology
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Cytokines / antagonists & inhibitors
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Cytokines / metabolism*
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HIV / drug effects
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Humans
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Magnetic Resonance Spectroscopy
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Plant Roots / chemistry
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Plants, Medicinal / chemistry*
Substances
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Anti-HIV Agents
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Coumarins
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Cytokines