Abstract
Selective substitution of a sulfur atom by carbon in a highly potent 13-membered cyclic disulfide was accomplished by intramolecular displacement of a bromide. The potency of the resulting thioethers in the VCAM/VLA-4 assay was dependent on ring size and the position of the sulfur atom.
MeSH terms
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Integrin alpha4beta1
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Integrins / antagonists & inhibitors*
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Molecular Mimicry
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Peptides, Cyclic / chemistry*
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Peptides, Cyclic / pharmacology*
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Receptors, Lymphocyte Homing / antagonists & inhibitors*
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Sulfides / chemistry*
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Vascular Cell Adhesion Molecule-1 / drug effects*
Substances
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Integrin alpha4beta1
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Integrins
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Peptides, Cyclic
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Receptors, Lymphocyte Homing
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Sulfides
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Vascular Cell Adhesion Molecule-1