The peroxisome proliferator-activated receptor gamma 2 Pro12Ala mutation is associated with early onset extreme obesity and reduced fasting glucose

Mol Genet Metab. 2000 Jun;70(2):159-61. doi: 10.1006/mgme.2000.2999.

Abstract

We screened the peroxisome proliferator activated receptor gamma 2 (PPAR gamma 2) for sequence variants in 165 unrelated obese (BMI >/= 30 kg/m(2)) Caucasian women, and 49 normal weight Caucasian female controls (BMI < 27 kg/m(2)). The allele frequency of the Pro12Ala mutation was higher in obese(18.18%) than in normal weight women (8. 16%) (chi(2)((1)) = 5.68, P = 0.017). Among obese women, the Pro12Ala mutation lowered age of obesity onset (Pro/Pro, 13.2 +/- 9. 4 years; Pro/Ala+Ala/Ala 8.6 +/- 7.1 years, P = 0.005), was associated with lower fasting glucose and was protective against type II diabetes.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Age of Onset
  • Alleles
  • Blood Glucose / metabolism*
  • DNA / analysis
  • Diabetes Mellitus, Type 2 / prevention & control
  • Female
  • Gene Frequency
  • Humans
  • Mutation*
  • Nuclear Proteins / genetics*
  • Obesity, Morbid / blood
  • Obesity, Morbid / ethnology
  • Obesity, Morbid / genetics*
  • Phenotype
  • Receptors, Cytoplasmic and Nuclear / genetics*
  • Transcription Factors / genetics*
  • White People

Substances

  • Blood Glucose
  • Nuclear Proteins
  • Receptors, Cytoplasmic and Nuclear
  • Transcription Factors
  • DNA