Effect of alcohol on growth of Plasmodium falciparum

Wien Klin Wochenschr. 2000 May 19;112(10):451-2.

Abstract

The effect of ethanol on the in vitro growth of the malaria parasite Plasmodium falciparum was investigated. 17 mM (0.08%) and 85 mM (0.39%) ethanol were added to parasite cultures and growth was determined for six days. A significant growth inhibition for both ethanol concentrations was observed on each day. It reached 65% for 85 mM ethanol after six days of incubation. Malarial parasites are strongly inhibited by ethanol concentrations which are attainable by extensive alcohol consumption.

MeSH terms

  • Africa / epidemiology
  • Alcohol Drinking*
  • Animals
  • Anti-Infective Agents / pharmacology*
  • Anti-Infective Agents / therapeutic use
  • Dose-Response Relationship, Drug
  • Drug Synergism
  • Ethanol / pharmacology*
  • Ethanol / therapeutic use
  • In Vitro Techniques
  • Malaria / prevention & control*
  • Plasmodium falciparum / drug effects*
  • Plasmodium falciparum / parasitology

Substances

  • Anti-Infective Agents
  • Ethanol