Abstract
1. This article gives a short overview of the physiology, pharmacology and the molecular biology of the human Na+/Cl(-)-dependent noradrenaline transporter (hNAT) and its gene. 2. Furthermore, naturally occurring variants of the hNAT are described and new results obtained through site-directed mutagenesis of the hNAT are presented, which increase our understanding about structural domains and amino acids critically involved in substrate, cosubstrate and inhibitor binding to the hNAT.
MeSH terms
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Adrenergic Uptake Inhibitors / pharmacology
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Animals
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Biogenic Monoamines / metabolism*
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Carrier Proteins / chemistry
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Carrier Proteins / genetics
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Carrier Proteins / metabolism*
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Desipramine / pharmacology
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Humans
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Mutation, Missense / genetics
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Neurotransmitter Agents / metabolism*
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Norepinephrine Plasma Membrane Transport Proteins
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Polymorphism, Genetic / genetics
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Symporters*
Substances
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Adrenergic Uptake Inhibitors
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Biogenic Monoamines
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Carrier Proteins
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Neurotransmitter Agents
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Norepinephrine Plasma Membrane Transport Proteins
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SLC6A2 protein, human
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Symporters
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Desipramine