A newly obtained sample of inclusive electron-nucleon scattering data has been analyzed for precision tests of quark-hadron duality. The data are in the nucleon resonance region, and span the range 0. 3<Q2<5.0 (GeV/c)(2). Duality is observed both in limited and extended regions around the prominent resonance enhancements. Higher twist contributions to the F2 structure function are found to be small on average, even in the low Q2 regime of approximately 0.5 (GeV/c)(2). Using duality, an average scaling curve is obtained. In all cases, duality appears to be a nontrivial property of the nucleon structure function.