Anxiety in major depression: relationship to suicide attempts

Am J Psychiatry. 2000 Oct;157(10):1614-8. doi: 10.1176/appi.ajp.157.10.1614.

Abstract

Objective: This study was an examination of the relationship of lifetime panic disorder and anxiety symptoms at index hospitalization to a history of a suicide attempt in patients with a major depressive episode.

Method: A total of 272 inpatients with at least one major depressive episode, with or without a history of a suicide attempt, were entered into the study. They were given structured diagnostic interviews for axis I and axis II disorders. Suicide attempt history, current psychopathology, and traits of aggression and impulsivity were also assessed.

Results: The rates of panic disorder did not differ in the suicide attempters and nonattempters. Agitation, psychic anxiety, and hypochondriasis were more severe in the nonattempter group. A multivariate analysis confirmed that this effect was independent of aggression and impulsivity.

Conclusions: Comorbid panic disorder in patients with major depression does not seem to increase the risk for lifetime suicide attempt. The presence of greater anxiety in the nonattempters warrants further investigation.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aged / psychology
  • Aged / statistics & numerical data*
  • Aggression / psychology
  • Anxiety Disorders / epidemiology*
  • Anxiety Disorders / psychology
  • Comorbidity
  • Depressive Disorder / epidemiology*
  • Depressive Disorder / psychology
  • Female
  • Humans
  • Male
  • Mental Disorders / diagnosis
  • Mental Disorders / epidemiology
  • Middle Aged
  • Panic Disorder / epidemiology
  • Panic Disorder / psychology
  • Personality Inventory / statistics & numerical data
  • Psychiatric Status Rating Scales / statistics & numerical data
  • Risk Factors
  • Severity of Illness Index
  • Suicide, Attempted / psychology
  • Suicide, Attempted / statistics & numerical data*