Polymorphic repeat in AIB1 does not alter breast cancer risk

Breast Cancer Res. 2000;2(5):378-85. doi: 10.1186/bcr82. Epub 2000 Jun 19.

Abstract

STATEMENT OF FINDINGS: We assessed the association between a glutamine repeat polymorphism in AIB1 and breast cancer risk in a case-control study (464 cases, 624 controls) nested within the Nurses' Health Study cohort. We observed no association between AIB1 genotype and breast cancer incidence, or specific tumor characteristics. These findings suggest that AIB1 repeat genotype does not influence postmenopausal breast cancer risk among Caucasian women in the general population.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Breast Neoplasms / epidemiology*
  • Breast Neoplasms / genetics
  • Case-Control Studies
  • DNA Primers / chemistry
  • DNA, Neoplasm / analysis
  • Female
  • Genotype
  • Glutamine / genetics
  • Humans
  • Linkage Disequilibrium
  • Microsatellite Repeats
  • Middle Aged
  • Nuclear Receptor Coactivator 3
  • Polymerase Chain Reaction
  • Polymorphism, Genetic*
  • Risk Factors
  • Sequence Analysis, DNA
  • Transcription Factors / genetics*

Substances

  • DNA Primers
  • DNA, Neoplasm
  • Transcription Factors
  • Glutamine
  • Nuclear Receptor Coactivator 3