Effect of ethanol on defibrillation energy requirements in humans

S A Strickberger; B E Bleske; T Davidson; E N Papasafakis; F Pelosi; G F Michaud; B P Knight; F Morady

doi:10.1016/s0002-9149(99)00621-9

Effect of ethanol on defibrillation energy requirements in humans

Am J Cardiol. 2000 Jan 1;85(1):117-9, A9. doi: 10.1016/s0002-9149(99)00621-9.

Authors

S A Strickberger¹, B E Bleske, T Davidson, E N Papasafakis, F Pelosi, G F Michaud, B P Knight, F Morady

Affiliation

¹ Department of Pharmacology, The University of Michigan Medical Center, Ann Arbor 48109-0022, USA.

PMID: 11078252
DOI: 10.1016/s0002-9149(99)00621-9

Abstract

The purpose of this double-blind study was to determine the effect of intravenous ethanol administration on defibrillation efficacy in 18 patients with an implantable defibrillator. The equivalent of 60 ml of 100 proof ethanol did not impair defibrillation efficacy.

Publication types

Clinical Trial
Randomized Controlled Trial

MeSH terms

Aged
Alcohol Drinking / adverse effects*
Alcohol Drinking / blood
Alcohol Drinking / metabolism
Cardiomyopathy, Dilated / complications*
Central Nervous System Depressants / administration & dosage
Central Nervous System Depressants / adverse effects*
Central Nervous System Depressants / blood
Coronary Disease / complications*
Defibrillators, Implantable*
Double-Blind Method
Drug Monitoring
Energy Metabolism*
Ethanol / administration & dosage
Ethanol / adverse effects*
Ethanol / blood
Female
Humans
Infusions, Intravenous
Male
Stroke Volume
Ventricular Fibrillation / etiology*
Ventricular Fibrillation / metabolism
Ventricular Fibrillation / physiopathology
Ventricular Fibrillation / therapy*

Substances

Central Nervous System Depressants
Ethanol