Multiple system atrophy/progressive supranuclear palsy: alpha-Synuclein, synphilin, tau, and APOE

Neurology. 2000 Dec 26;55(12):1918-20. doi: 10.1212/wnl.55.12.1918.

Abstract

Article abstract-Alpha synuclein, tau, synphilin, and APOE genotypes were analyzed in patients with multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) and controls. The predisposing effect of the tau insertion polymorphism to the development of PSP is confirmed. However, no effect of alpha-synuclein, synphilin, or APOE variability on the development of PSP, or of tau, alpha-synuclein, APOE, or synphilin gene variability on the development of MSA, are demonstrated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apolipoproteins E / genetics*
  • Carrier Proteins / genetics*
  • Genotype
  • Humans
  • Multiple System Atrophy / genetics*
  • Nerve Tissue Proteins / genetics*
  • Polymorphism, Genetic
  • Supranuclear Palsy, Progressive / genetics*
  • Synucleins
  • alpha-Synuclein
  • tau Proteins / genetics*

Substances

  • Apolipoproteins E
  • Carrier Proteins
  • Nerve Tissue Proteins
  • SNCA protein, human
  • SNCAIP protein, human
  • Synucleins
  • alpha-Synuclein
  • tau Proteins