[Observation on inhibitory effect of tetrandrine on the growth of human skin fibroblast in vitro]

Zhongguo Zhong Yao Za Zhi. 1998 Jan;23(1):55-7, 64.
[Article in Chinese]

Abstract

The effect of tetrandrine on the growth of human skin fibroblasts was observed in vitro culture. The result revealed that tetrandrine significantly inhibited the growth of fibroblast. The higher the concentration of tetrandrine, the higher the inhibition rate, forming a time-dependent relationship. The possible value of tetrandrine in the treatment of hypertrophic scar is discussed.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / administration & dosage
  • Alkaloids / pharmacology*
  • Benzylisoquinolines*
  • Calcium Channel Blockers / administration & dosage
  • Calcium Channel Blockers / pharmacology*
  • Cell Division / drug effects
  • Cells, Cultured
  • Dose-Response Relationship, Drug
  • Fibroblasts / cytology*
  • Humans
  • Skin / cytology*
  • Time Factors

Substances

  • Alkaloids
  • Benzylisoquinolines
  • Calcium Channel Blockers
  • tetrandrine