In this study, the general toxicity tests including cytotoxicity, haemolysis and oral mucous irratation of the Ti-Zr alloy were investigated. The results showed the level of cytotoxicity was grade 0, the haemolysis degree was 0.15% and no histomorphologic change was observed in the animals of Ti-Zr alloy groups. These data indicate that Ti-Zr alloy has good biocompatibility as a dental material.