Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls

P Sklar; S G Schwab; N M Williams; M Daly; S Schaffner; W Maier; M Albus; M Trixler; P Eichhammer; B Lerer; J Hallmayer; N Norton; H Williams; S Zammit; A G Cardno; S Jones; G McCarthy; V Milanova; G Kirov; M C O'Donovan; E S Lander; M J Owen; D B Wildenauer

doi:10.1038/88836

Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls

Nat Genet. 2001 Jun;28(2):126-8. doi: 10.1038/88836.

Authors

Affiliation

¹ Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA. sklar@genome.wi.mit.edu

PMID: 11381257
DOI: 10.1038/88836

Abstract

A genetic association between NOTCH4 and schizophrenia has previously been proposed. Unsing all markers previously shown to be associated, we found no evidence for such in three independent family-based samples (n=519 parent-offspring trios), and a case-control sample derived from the same ethnic background as the original observation. These data strongly suggest that NOTCH4 is not a significant susceptibility allele for schizophrenia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Case-Control Studies
Chromosomes, Human, Pair 6
Genetics, Population
Humans
Linkage Disequilibrium*
Microsatellite Repeats
Polymorphism, Genetic
Proto-Oncogene Proteins / genetics*
Receptor, Notch4
Receptors, Cell Surface*
Receptors, Notch
Schizophrenia / genetics*
United Kingdom

Substances

NOTCH4 protein, human
Proto-Oncogene Proteins
Receptor, Notch4
Receptors, Cell Surface
Receptors, Notch