Background: Hyperglycaemia in type 2 diabetes results from reduced beta-cell function and insulin resistance. The treatment of type 2 diabetes must be targeted against both conditions to reduce symptoms of hyperglycaemia and the risk of diabetic late complications.
Material and methods: In this review we cover the recent scientific documentation from long term studies on treatment effects. We also discuss the different treatments available.
Results: Recent clinical trials have shown that lowering blood glucose levels over time significantly reduces development of microvascular complications in type 2 diabetes. There are several treatment options available which make adequate blood glucose control possible in patients with type 2 diabetes.
Interpretation: A reduction in the development of microvascular complications in type 2 diabetes is an achievable goal.