Abstract
Neurogenic genes in the Notch receptor-mediated signaling pathway play important roles in neuronal cell fate specification as well as neuronal differentiation. The Drosophila neuralized gene is one of the neurogenic genes. We have cloned a mouse homolog of Drosophila neuralized, m-neu1, and found that the m-neu1 transcript is expressed in differentiated neurons. Mice deficient for m-neu1 are viable and morphologically normal, but exhibit specific defects in olfactory discrimination and hypersensitivity to ethanol. These findings reveal an essential role of m-neu1 in ensuring proper processing of certain information in the adult brain.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Ataxia / chemically induced
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Ataxia / genetics
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Avoidance Learning
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Blotting, Northern
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Brain Chemistry
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DNA, Complementary / genetics
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Discrimination, Psychological*
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Drosophila Proteins*
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Drosophila melanogaster / genetics
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Drug Resistance / genetics
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Ethanol / toxicity*
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Gene Library
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Genotype
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Hemiterpenes
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Insect Proteins / genetics
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Ligases*
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Male
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Maze Learning
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Molecular Sequence Data
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Nerve Tissue Proteins / deficiency
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Nerve Tissue Proteins / genetics
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Nerve Tissue Proteins / physiology*
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Neurons / metabolism
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Odorants
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Olfaction Disorders / genetics*
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Pentanoic Acids
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Reverse Transcriptase Polymerase Chain Reaction
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Sequence Alignment
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Sequence Homology, Amino Acid
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Smell / genetics*
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Species Specificity
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Ubiquitin-Protein Ligases*
Substances
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DNA, Complementary
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Drosophila Proteins
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Hemiterpenes
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Insect Proteins
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Nerve Tissue Proteins
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Pentanoic Acids
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isovaleric acid
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Ethanol
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Ubiquitin-Protein Ligases
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neur protein, Drosophila
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Ligases