An ALS-like syndrome with new HIV infection and complete response to antiretroviral therapy

Neurology. 2001 Sep 25;57(6):1094-7. doi: 10.1212/wnl.57.6.1094.

Abstract

A 32-year-old woman presenting with a rapidly progressive ALS-like syndrome was found to be HIV positive with a CD4 count of 44/mm(3). The patient recovered completely during 1 year after treatment with nelfinavir, zidovudine, and lamivudine, and recovery is sustained nearly 4 years later. Recovery was accompanied by HIV RNA becoming undetectable in plasma and CSF.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-HIV Agents / therapeutic use*
  • Brain / pathology
  • Drug Therapy, Combination
  • Female
  • Follow-Up Studies
  • HIV Infections / diagnosis
  • HIV Infections / drug therapy*
  • Humans
  • Lamivudine / therapeutic use
  • Magnetic Resonance Imaging
  • Motor Neuron Disease / diagnosis
  • Motor Neuron Disease / drug therapy*
  • Nelfinavir / therapeutic use
  • Neurologic Examination / drug effects
  • Treatment Outcome
  • Zidovudine / therapeutic use

Substances

  • Anti-HIV Agents
  • Lamivudine
  • Zidovudine
  • Nelfinavir