Abstract
Phosphoinositide 3 kinases (PI3Ks)*Abbreviation used in this paper: PI3K, phosphoinositide 3 kinase. are known as regulators of phagocytosis. Recent results demonstrate that class I and III PI3Ks act consecutively in phagosome formation and maturation, and that their respective products, phosphatidylinositol 3,4,5-trisphosphate (PI[3,4,5]P(3)) and phosphatidylinositol 3-phosphate (PI[3]P), accumulate transiently at different stages. Phagosomes containing Mycobacterium tuberculosis do not acquire the PI(3)P-binding protein EEA1, which is required for phagosome maturation. This suggests a possible mechanism of how this microorganism evades degradation in phagolysosomes.
Publication types
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Comment
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Research Support, Non-U.S. Gov't
MeSH terms
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Humans
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Immunoglobulin G / metabolism
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Membrane Proteins / metabolism
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Models, Biological
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Molecular Structure
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Mycobacterium tuberculosis / metabolism
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Phagocytes / metabolism
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Phagocytes / microbiology
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Phagocytes / ultrastructure
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Phagocytosis / physiology*
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Phagosomes / metabolism
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Phagosomes / microbiology
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Phagosomes / ultrastructure
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Phosphatidylinositol 3-Kinases / metabolism*
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Phosphatidylinositol Phosphates / metabolism*
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Vesicular Transport Proteins
Substances
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Immunoglobulin G
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Membrane Proteins
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Phosphatidylinositol Phosphates
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Vesicular Transport Proteins
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early endosome antigen 1
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Phosphatidylinositol 3-Kinases