Abnormal electrolyte concentrations occur commonly in hospitalized patients and may produce a variety of clinical symptoms, cause lack of response to therapeutics for primary clinical conditions, and affect clinical outcome. Recognition of electrolyte disturbances requires a high index of suspicion by the clinician for such a disturbance and prompt therapy to ensure a positive and timely outcome for the patient. This article discusses electrolyte abnormalities that occur in critically ill patients, with a review of diseases commonly associated with each electrolyte disturbance, and their recommended management.