Chemokine receptor expression on B cells and effect of interferon-beta in multiple sclerosis

J Neuroimmunol. 2002 Jan;122(1-2):125-31. doi: 10.1016/s0165-5728(01)00453-2.

Abstract

We investigated the B-cell expression of chemokine receptors CXCR3, CXCR5 and CCR5 in the blood and cerebrospinal fluid (CSF) from patients in relapse of multiple sclerosis (MS) and in neurological controls. Chemokine receptor expression was also studied in interferon-beta-treated patients with relapsing-remitting or secondary progressive MS. We observed significantly higher expression of CXCR3 on B cells in the CSF in active MS than in controls. Patients with active MS also had higher B-cell expression of CCR5 in blood. No major differences between RRMS and SPMS patients were detected, and chemokine receptor expression was not affected by interferon-beta treatment.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adjuvants, Immunologic / administration & dosage*
  • Adult
  • B-Lymphocytes / metabolism*
  • Cerebrospinal Fluid / cytology
  • Cerebrospinal Fluid / immunology
  • Demyelinating Diseases / drug therapy
  • Demyelinating Diseases / immunology
  • Female
  • Flow Cytometry
  • Humans
  • Interferon-beta / administration & dosage*
  • Male
  • Middle Aged
  • Multiple Sclerosis, Chronic Progressive / drug therapy*
  • Multiple Sclerosis, Chronic Progressive / immunology
  • Multiple Sclerosis, Relapsing-Remitting / drug therapy*
  • Multiple Sclerosis, Relapsing-Remitting / immunology
  • Receptors, CCR5 / biosynthesis
  • Receptors, CXCR3
  • Receptors, CXCR5
  • Receptors, Chemokine / biosynthesis*
  • Receptors, Cytokine / biosynthesis

Substances

  • Adjuvants, Immunologic
  • CXCR3 protein, human
  • CXCR5 protein, human
  • Receptors, CCR5
  • Receptors, CXCR3
  • Receptors, CXCR5
  • Receptors, Chemokine
  • Receptors, Cytokine
  • Interferon-beta