Lipoamino acid-based adjuvant carrier system: enhanced immunogenicity of group a streptococcal peptide epitopes

Aniko Horvath; Colleen Olive; Allan Wong; Timothy Clair; Penny Yarwood; Michael Good; Istvan Toth

doi:10.1021/jm0110441

Lipoamino acid-based adjuvant carrier system: enhanced immunogenicity of group a streptococcal peptide epitopes

J Med Chem. 2002 Mar 14;45(6):1387-90. doi: 10.1021/jm0110441.

Authors

Aniko Horvath¹, Colleen Olive, Allan Wong, Timothy Clair, Penny Yarwood, Michael Good, Istvan Toth

Affiliation

¹ School of Pharmacy, The University of Queensland, Brisbane QLD 4072, Australia.

PMID: 11882009
DOI: 10.1021/jm0110441

Abstract

Lipoamino acid-based synthetic peptides (lipid core peptides, LCP) derived from the type-specific and conserved region determinants of group A streptococci (GAS) were evaluated as potential candidate sequences in a vaccine to prevent GAS-associated diseases, including rheumatic heart disease and poststreptococcal acute glomerulonephritis. The LCP peptides had significantly enhanced immunogenicity as compared with the monomeric peptide epitopes. Furthermore, the peptides incorporated into the LCP system generated epitope-specific antibodies without the use of any conventional adjuvant.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adjuvants, Immunologic / chemical synthesis*
Adjuvants, Immunologic / pharmacology
Amino Acid Sequence
Animals
Antibodies, Bacterial / blood
Bacterial Vaccines / immunology*
Bacterial Vaccines / standards
Epitopes / immunology*
Female
Humans
Mice
Molecular Sequence Data
Peptides / chemical synthesis
Peptides / immunology*
Streptococcal Infections / immunology*
Streptococcal Infections / prevention & control
Streptococcus pyogenes / immunology*

Substances

Adjuvants, Immunologic
Antibodies, Bacterial
Bacterial Vaccines
Epitopes
Peptides