This article has three aims, the first of which is to provide an overview of the assessment and management of chronic nausea and vomiting. Second, it details the definitions, approach to assessment, diagnostic classifications, and treatment options of patients with nausea and vomiting. Finally, specific emphasis is placed on chronic drug refractory nausea and vomiting (gastroparesis) and the clinical cost and quality of life data associated with gastric electric stimulation.