Abstract
The FYVE zinc finger domain is conserved from yeast (five proteins) to man (27 proteins). It functions in the membrane recruitment of cytosolic proteins by binding to phosphatidylinositol 3-phosphate (PI3P), which is found mainly on endosomes. Here we review recent work that sheds light on the targeting of FYVE finger proteins to PI3P-containing membranes, and how these proteins serve to regulate multiple cellular functions.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Binding Sites
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Humans
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Models, Molecular
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Molecular Sequence Data
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Nematoda
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Phosphatidylinositol 3-Kinases / chemistry
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Phosphatidylinositol 3-Kinases / metabolism*
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Phosphatidylinositol Phosphates / metabolism*
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Protein Conformation
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Protein Kinases / chemistry
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Protein Kinases / metabolism
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Protein Structure, Secondary
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Saccharomyces cerevisiae / metabolism
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Sequence Alignment
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Sequence Homology, Amino Acid
Substances
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Phosphatidylinositol Phosphates
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phosphatidylinositol 3-phosphate
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Protein Kinases
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PIKFYVE protein, human