Abstract
ATP-dependent chromatin remodeling enzymes, such as SWI/SNF, hydrolyze thousands of ATPs to regulate gene expression on chromatin fibers. Recent mechanistic studies suggest that these enzymes generate localized changes in DNA topology that drive formation of multiple, remodeled nucleosomal states.
MeSH terms
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Adenosine Triphosphate / metabolism*
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Chromatin / physiology*
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DNA / metabolism
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DNA Helicases
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Histones / metabolism
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Humans
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Nuclear Proteins / metabolism*
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Nucleosomes
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Transcription Factors / metabolism*
Substances
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Chromatin
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Histones
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Nuclear Proteins
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Nucleosomes
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Transcription Factors
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Adenosine Triphosphate
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DNA
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SMARCA4 protein, human
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DNA Helicases