Chromatin remodeling: nucleosomes bulging at the seams

Curr Biol. 2002 Apr 2;12(7):R245-7. doi: 10.1016/s0960-9822(02)00782-0.

Abstract

ATP-dependent chromatin remodeling enzymes, such as SWI/SNF, hydrolyze thousands of ATPs to regulate gene expression on chromatin fibers. Recent mechanistic studies suggest that these enzymes generate localized changes in DNA topology that drive formation of multiple, remodeled nucleosomal states.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphate / metabolism*
  • Chromatin / physiology*
  • DNA / metabolism
  • DNA Helicases
  • Histones / metabolism
  • Humans
  • Nuclear Proteins / metabolism*
  • Nucleosomes
  • Transcription Factors / metabolism*

Substances

  • Chromatin
  • Histones
  • Nuclear Proteins
  • Nucleosomes
  • Transcription Factors
  • Adenosine Triphosphate
  • DNA
  • SMARCA4 protein, human
  • DNA Helicases