Characterization of plasmids carrying CMY-2 from expanded-spectrum cephalosporin-resistant Salmonella strains isolated in the United States between 1996 and 1998

Antimicrob Agents Chemother. 2002 May;46(5):1269-72. doi: 10.1128/AAC.46.5.1269-1272.2002.

Abstract

Sequencing of DNA from 15 expanded-spectrum cephalosporin (e.g., ceftriaxone)-resistant Salmonella isolates obtained in the United States revealed that resistance to ceftriaxone in all isolates was mediated by cmy-2. Hybridization patterns revealed three plasmid structures containing cmy-2 in these 15 isolates. These data suggest that the spread of cmy-2 among Salmonella strains is occurring through mobilization of the cmy-2 gene into different plasmid backbones and consequent horizontal transfer by conjugation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ceftriaxone / pharmacology
  • Cephalosporin Resistance / genetics*
  • Cephalosporins / pharmacology
  • Conjugation, Genetic
  • Drug Resistance, Multiple, Bacterial
  • Humans
  • Microbial Sensitivity Tests
  • Plasmids / genetics*
  • Salmonella / drug effects*
  • Salmonella / genetics
  • Salmonella / isolation & purification
  • Salmonella Infections / microbiology
  • Salmonella typhimurium / drug effects
  • Salmonella typhimurium / genetics
  • Salmonella typhimurium / isolation & purification
  • United States
  • beta-Lactamases / genetics*

Substances

  • Cephalosporins
  • Ceftriaxone
  • beta-lactamase CMY-2
  • beta-Lactamases