Abstract
Sequencing of DNA from 15 expanded-spectrum cephalosporin (e.g., ceftriaxone)-resistant Salmonella isolates obtained in the United States revealed that resistance to ceftriaxone in all isolates was mediated by cmy-2. Hybridization patterns revealed three plasmid structures containing cmy-2 in these 15 isolates. These data suggest that the spread of cmy-2 among Salmonella strains is occurring through mobilization of the cmy-2 gene into different plasmid backbones and consequent horizontal transfer by conjugation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Ceftriaxone / pharmacology
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Cephalosporin Resistance / genetics*
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Cephalosporins / pharmacology
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Conjugation, Genetic
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Drug Resistance, Multiple, Bacterial
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Humans
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Microbial Sensitivity Tests
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Plasmids / genetics*
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Salmonella / drug effects*
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Salmonella / genetics
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Salmonella / isolation & purification
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Salmonella Infections / microbiology
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Salmonella typhimurium / drug effects
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Salmonella typhimurium / genetics
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Salmonella typhimurium / isolation & purification
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United States
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beta-Lactamases / genetics*
Substances
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Cephalosporins
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Ceftriaxone
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beta-lactamase CMY-2
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beta-Lactamases