Correspondence re: Raida, M. et al., prevalence of a common point mutation in the dihydropyrimidine dehydrogenase (DPD) gene within the 5'-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)-related toxicity compared with controls

Clin Cancer Res. 2002 May;8(5):1314; author reply 1315-6.
No abstract available

Publication types

  • Comment
  • Letter

MeSH terms

  • Alternative Splicing / genetics
  • Antimetabolites, Antineoplastic / adverse effects*
  • Antimetabolites, Antineoplastic / therapeutic use
  • Diarrhea / chemically induced
  • Diarrhea / pathology
  • Dihydrouracil Dehydrogenase (NADP)
  • Fluorouracil / adverse effects*
  • Fluorouracil / therapeutic use
  • Gene Frequency
  • Genotype
  • Humans
  • Introns / genetics
  • Leukopenia / chemically induced
  • Leukopenia / pathology
  • Neoplasms / drug therapy
  • Neoplasms / enzymology
  • Neoplasms / genetics
  • Oxidoreductases / genetics*
  • Point Mutation
  • Severity of Illness Index
  • Stomatitis / chemically induced
  • Stomatitis / pathology
  • Thrombocytopenia / chemically induced
  • Thrombocytopenia / pathology

Substances

  • Antimetabolites, Antineoplastic
  • Oxidoreductases
  • Dihydrouracil Dehydrogenase (NADP)
  • Fluorouracil