Oviedomycin, an unusual angucyclinone encoded by genes of the oleandomycin-producer Streptomyces antibioticus ATCC11891

J Nat Prod. 2002 May;65(5):779-82. doi: 10.1021/np010555n.

Abstract

Our investigations on the discovery of novel natural metabolites using type II polyketide synthase gene probes (actI/III) yielded an unusual angucyclinone, oviedomycin (2), when applied to the oleandomycin (1) producer Streptomyces antibioticus ATCC11891. The novel natural product was produced using S. albus R(-)M(-) as a host strain, into which a cosmid containing the oviedomycin gene cluster was transformed. Its structure was elucidated by NMR spectroscopy and mass spectrometry.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aminoglycosides / chemistry
  • Aminoglycosides / isolation & purification*
  • Ethers, Cyclic / chemistry
  • Ethers, Cyclic / isolation & purification*
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Molecular Structure
  • Multienzyme Complexes / genetics
  • Multienzyme Complexes / metabolism
  • Nuclear Magnetic Resonance, Biomolecular
  • Spectrophotometry, Ultraviolet
  • Spectroscopy, Fourier Transform Infrared
  • Streptomyces antibioticus / genetics*
  • Streptomyces antibioticus / metabolism*

Substances

  • Aminoglycosides
  • Ethers, Cyclic
  • Multienzyme Complexes
  • oviedomycin