Challenges in developing a molecular characterization of cancer

Semin Oncol. 2002 Jun;29(3):280-5. doi: 10.1053/sonc.2002.32903.

Abstract

DNA microarrays are widely used to measure gene expression across thousands of genes in parallel. Recently, considerable efforts have been made to utilize this technology to improve our understanding of cancer and to identify novel diagnostic markers and therapeutic targets. Here, we detail some of the challenges in developing a molecular characterization of cancer and in translating these new discoveries towards clinical utility.

Publication types

  • Review

MeSH terms

  • Gene Expression Profiling*
  • Humans
  • Neoplasms / diagnosis
  • Neoplasms / genetics*
  • Oligonucleotide Array Sequence Analysis*