Abstract
Pioneering work suggests that a synaptic active zone protein, RIM1, regulates both short- and long-term glutamatergic presynaptic plasticity at certain synapses. In short-term plasticity, RIM1 accelerates the priming of synaptic vesicles for fusion; by contrast, in long-term potentiation of mossy fiber synapses in the hippocampal CA3 region, phosphorylated RIM1 acts through an unknown molecular pathway to enhance release of the excitatory neurotransmitter glutamate.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Exocytosis / physiology
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GTP-Binding Proteins*
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Humans
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Long-Term Potentiation / physiology
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Mossy Fibers, Hippocampal / metabolism*
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Mossy Fibers, Hippocampal / ultrastructure
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Nerve Tissue Proteins / genetics
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Nerve Tissue Proteins / metabolism*
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Synaptic Membranes / metabolism*
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Synaptic Membranes / ultrastructure
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Synaptic Transmission / physiology*
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Synaptic Vesicles / metabolism*
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Synaptic Vesicles / ultrastructure
Substances
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Nerve Tissue Proteins
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RIMS1 protein, human
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Rim protein, mammalian
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Rims1 protein, rat
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UNC13B protein, human
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GTP-Binding Proteins