Abstract
Two polymer-supported reagents for methylphosphorylation and phosphorylation of carbohydrates have been developed. p-Hydroxybenzyl alcohol and beta-mercaptoethanol were immobilized on cross-linked divinylbenzene-polystyrene copolymer and conjugated with methyl N,N-diisopropylchlorophosphoramidite. Carbohydrates were reacted with polymer-bound phosphitylating reagents. Further oxidation, with or without the methoxy group deprotection, and cleavage yielded methylphosphorylated or phosphorylated carbohydrates, respectively.
MeSH terms
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Benzyl Alcohols / chemistry
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Carbohydrates / chemistry*
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Chemistry, Organic / methods
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Hydrocarbons, Chlorinated / chemistry
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Mercaptoethanol / chemistry
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Organophosphates / chemical synthesis
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Organophosphorus Compounds / chemistry
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Oxidation-Reduction
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Phosphorylation
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Polymers / chemistry*
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Polystyrenes / chemistry
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Styrene / chemistry
Substances
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Benzyl Alcohols
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Carbohydrates
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Hydrocarbons, Chlorinated
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Organophosphates
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Organophosphorus Compounds
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Polymers
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Polystyrenes
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phosphoramidite
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4-hydroxybenzyl alcohol
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Styrene
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Mercaptoethanol