Endometrial cancer has typically been regarded as a relatively benign disease. However, survival rates for patients with advanced-stage or recurrent disease are very poor and more adequate systemic treatment is certainly needed. Being a tumor that arises from a hormone responsive tissue, endometrial cancer is a logical target for endocrine manipulation. This article gives an overview of our current knowledge on hormonal therapy and highlights the large potential for improvement in results of such therapy. Target areas for future research are described.